Mar 18, 2019 · In one study, 15 women who were less than 1 week postpartum took indomethacin in dosages ranging from 75 mg orally to 300 mg rectally daily (0.94 to 4.29 mg/kg daily). Milk samples were taken before and after feeding at times ranging from 0.7 to 21.4 hours after the last dose. In 11 of the women, indomethacin was undetectable (7.9/10. In one study, 15 women who were less than 1 week postpartum took indomethacin in dosages ranging from 75 mg orally to 300 mg rectally daily (0.94 to 4.29 mg/kg daily). Milk samples were taken before and after feeding at times ranging from 0.7 to 21.4 hours after the last dose. In 11 of the women, indomethacin was undetectable (20 mcg/L) in milk.
Aug 02, 2019 · Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. How is this medicine (Indomethacin Suppositories) best taken? Use this medicine (indomethacin suppositories) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Use suppository rectally.7.9/10. Furthermore, indomethacin passes into breast milk and may affect a nursing baby. Do not take indomethacin without first talking to your doctor if you are breast-feeding a baby. Avoid prolonged exposure to sunlight. Indomethacin may increase the sensitivity of the skin to sunlight.
1. The excretion of indomethacin into breast milk and subsequent exposure of infants was studied in 16 women and seven of their infants. The median milk:plasma ratio in seven patients where there were measurable drug concentrations in both milk and plasma was 0.37. 2. Total infant dose, assuming a Cited by: 56. Study design. Infants were eligible for the study if they were 23 1/7 – 30 6/7 weeks gestation, weighed 401–1250 g at birth, received maximum enteral volumes ≤60 ml/kg/day and were about to be treated with indomethacin or ibuprofen. A standardized “feeding advance regimen” and guidelines for managing feeding intolerance were followed at each site (n=13).Cited by: 67.
Stop taking indomethacin and get medical help right away if you notice any of the following rare but serious side effects: Consult your doctor before breast-feeding. Related Links. Indomethacin is secreted into human breast milk and is not recommended in mothers who are breast-feeding. Of note, intravenous indomethacin is used therapeutically short-term in neonates, including premature neonates, at doses significantly higher than those that would be delivered via breast milk.